A clear, descriptive title is important to allow readers and users to readily identify the scope and relevance of the review. The clearer and more specific a title is, the more readily a reader will be able to make decisions about the potential relevance of the systematic review. The protocol title should accurately describe and reflect the content of the review protocol and include relevant information with regards the types of participants, types of interventions and comparators and the outcomes considered in the review. The title should be concise and should not be phrased as a question. The title of the review protocol should explicitly identify the publication as a protocol for a systematic review. The following convention is recommended: ‘a protocol for a systematic review’. Following the guidance mentioned, for systematic reviews of effectiveness we recommend the following convention: 'The effectiveness of [intervention] compared to [comparator] on [outcome]: a protocol for a systematic review'.